DEVELOPMENT AND APPLICATION OF A MODULAR ENZYMATIC LABELING PROCESS FOR THE ANALYSIS OF DIVERSE DNA BASE MODIFICATIONS
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- title
- DEVELOPMENT AND APPLICATION OF A MODULAR ENZYMATIC LABELING PROCESS FOR THE ANALYSIS OF DIVERSE DNA BASE MODIFICATIONS
- author
- Wang, Fanny
- abstract
- There exists a large diversity of DNA base modifications, but the ability to study these modifications and their effects on disease development and progression has thus far been limited. Most techniques are only able to examine a few specific modifications, and some methods are destructive to the sample, precluding the possibility of additional analysis.
- subject
- DNA base modifications
- glycosylase
- labeling
- nanopore
- oxidative damage
- qPCR
- contributor
- Hall, Adam R (committee chair)
- Furdui, Cristina M (committee member)
- Kohli, Rahul M (committee member)
- Lu, Chang (committee member)
- Perrino, Fred W (committee member)
- Rahbar, Elaheh (committee member)
- date
- 2021-01-13T09:35:28Z (accessioned)
- 2021-01-13T09:35:28Z (available)
- 2021 (issued)
- degree
- Biomedical Engineering (discipline)
- identifier
- http://hdl.handle.net/10339/97957 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- type
- Dissertation